工业微生物技术

高超

教授
博士/硕士生导师
0532-58631559
个人简介 科研项目 学术论文 其他介绍

教育背景

博士 起止时间:2004-2009毕业院校:bet365 코리아 专业:发酵工程

硕士 起止时间: 毕业院校: 专业:

学士 起止时间:2000-2004毕业院校:bet365 코리아 专业:生物技术


工作经历

起止时间 单位名称 专业技术职务 

2010-2011 上海交通大学 博士后

2012至今 bet365 코리아 教授


研究方向

微生物生理与代谢

生物催化

系统代谢工程

科研项目

1. 2021.01-2025.12,bet365 코리아杰出中青年学者学科建设经费

2. 2020.01-2024.12,微生物进化改造技术开发及抗逆元件挖掘,国家重点研发计划子课题

3. 2020.01-2023.12,大肠杆菌中D-2-羟基戊二酸分解代谢机制研究,国家自然科学基金面上项目

4. 2019.01-2020.12,代谢工程改造产酸克雷伯氏菌高效生产丙酮酸,山东省重点研发计划

5. 2019.01-2023.12,bet365 코리아齐鲁青年学者学科建设经费

6. 2018.04-2021.06,微生物2-羟基羧酸分解代谢的应用基础研究,山东省杰出青年基金

7. 2015.01-2018.12,恶臭假单胞菌中一条新的戊二酸代谢途径,国家自然科学基金面上项目

8. 2014.07-2016.12,赖氨酸生物转化生产5-氨基戊酸,国家高技术研究发展计划

9. 2013.01-2016.12,新型NAD非依赖性D-乳酸脱氢酶催化机理及应用基础研究,国家自然科学基金面上项目

10. 2012.11-2015.12,2-丁醇工程菌的基因组规模系统代谢育种,国家高技术研究发展计划

11. 2015.07-2020.06,铜绿假单胞菌L-乳酸代谢关键酶调控机制,bet365 코리아青年学者未来计划

代表性论文

1. Zhang Manman, Kang Zhaoqi, Guo Xiaoting, Guo Shiting, Xiao Dan, Liu Yidong, Ma Cuiqing, Xu Ping,Gao Chao*. Regulation of glutarate catabolism by GntR family regulator CsiR and LysR family regulator GcdR inPseudomonas putida KT2440.mBio. 2019, 10, e01570-19

2. Li Zhong, Yan Jinxin, Sun Jinkai, Xu Ping, Ma Cuiqing,Gao Chao*. Production of value-added chemicals from glycerol using in vitro enzymatic cascades.Commu. Chem. 2018, 1, 71

3. Guo Xiaoting, Zhang Manman, Cao Menghao, Zhang Wen, Kang Zhaoqi, Xu Ping, Ma Cuiqing,Gao Chao*, D-2-Hydroxyglutarate dehydrogenase plays a dual role in L-serine biosynthesis and D-malate utilization in the bacteriumPseudomonas stutzeri.J. Biol. Chem.2018, 293, 15513–15523

4. Zhang Manman,Gao Chao*, Guo Xiaoting, Guo Shiting, Kang Zhaoqi, Xiao Dan, Yan Jinxin, Zhang Wen, Tao Fei, Dong Wenyue, Liu Pan, Yang Chen, Ma Cuiqing, Xu Ping*, Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate.Nat. Commu. 2018, 9, 2114.

5. Zhang Wen, Zhang Manman,Gao Chao*, Zhang Yipeng, Ge Yongsheng, Guo Shiting, Guo Xiaoting, Zhou Zikang, Liu Qiuyuan, Zhang Yingxin, Ma Cuiqing, Tao Fei, Xu Ping*, Coupling between D-3-phosphoglycerate dehydrogenase and D-2-hydroxyglutarate dehydrogenase drives bacterial L-serine synthesis.Proc Natl Acad Sci U S A. 2017, 114, E7574-E7582.

6. Jiang Tianyi, Guo Xiaoting, Yan Jinxin, Zhang Yingxin, Wang Yujiao, Zhang Manman, Sheng Binbin, Ma Cuiqing, Xu Ping,Gao Chao*, A bacterial multidomain NAD-independent D-lactate dehydrogenase utilizes flavin adenine dinucleotide and Fe-S clusters as cofactors and quinone as an electron acceptor for D-lactate oxidization.J. Bacteriol. 2017, 199, e00342-17.

7. Li Zhong, Zhang Manman, Jiang Tongtong, Sheng Binbin, Ma Cuiqing, Xu Ping,Gao Chao*, Enzymatic cascades for efficient biotransformation of racemic lactate derived from corn steep water.ACS Sustainable Chem. Eng. 2017, 5, 3456−3464

8. Ge Yongsheng, Li Kun, Li Lixiang,Gao Chao*, Lijie Zhang, Ma Cuiqing*, Xu Ping, Contracted but effective: production of enantiopure 2,3-butanediol by thermophilic and GRASBacillus licheniformis.Green Chem. 2016, 18, 4693-4703

9. Sheng Binbin, Xu Jing, Ge Yongsheng, Zhang Shuo, Wang Danqi,Gao Chao*, Ma Cuiqing, Xu Ping. Enzymatic resolution by a D-lactate oxidase catalyzed reaction for (S)-2-hydroxycarboxylic acids.ChemCatChem. 2016, 8, 2630 – 2633

10. Gao Chao, Li Zhong, Zhang Lijie, Wang Chao, Li Kun, Ma Cuiqing*, Xu Ping, An artificial enzymatic reaction cascade for a cell-free bio-system based on glycerol,Green Chem. 2015, 17, 804-807

11. Gao Chao, Wang Yujiao, Zhang Yingxin, Lv Min, Dou Peipei, Xu Ping, Ma Cuiqing*, NAD-Independent L-lactate dehydrogenase required for L-lactate utilization in Pseudomonas stutzeriA1501.J. Bacteriol. 2015, 197, 2239–224712.

12. Sheng Binbin, Xu Jing, Zhang Yingxin, Jiang Tianyi, Deng Sisi, Kong Jian,Gao Chao*, Ma Cuiqing, Xu Ping, Utilization of D-lactate as an energy source supports the growth ofGluconobacter oxydans,Appl. Environ. Microbiol. 2015, 81, 4098-4110

获奖情况

2021年bet365 코리아杰出中青年学者

2020年教育部青年长江学者

2019年bet365 코리아齐鲁青年学者

2018年山东省杰出青年科学基金

2015年bet365 코리아青年学者未来计划

2015年度山东省暨bet365 코리아优秀硕士学位论文指导教师

2020年度山东省暨bet365 코리아优秀硕士学位论文指导教师


所获专利

一株重组大肠杆菌及其在生产2-丁醇中的应用,ZL201510713808.9

一种加速5-氨基戊酸生物法生产的方法,ZL201610628388.9

一种D-乳酸氧化酶及其在D-乳酸检测中的应用,ZL201510135775.4

一株基因工程菌及其在生产(2R,3R)-2,3-丁二醇中的应用,ZL201410314730.9

一种利用L-赖氨酸2-单加氧酶和δ-戊酰胺水解酶催化制备5-氨基戊酸方法,ZL201310241389.4