教育背景:
1、2013/01-2015/07,丹麦哥本哈根大学,生物学院,博士,导师: Qunxin She
2、2008/09-2015/06,bet365 코리아,生命科学学院,博士,导师:申玉龙
3、2004/09-2008/06,bet365 코리아,生命科学学院,学士
工作经历:
1、2023/09-至今,bet365 코리아,bet365 코리아,副教授
2、2018/03-2023/08,bet365 코리아,bet365 코리아,助理研究员
3、2016/01-2018/02,bet365 코리아,bet365 코리아,博士后,合作导师:申玉龙
研究方向:
·嗜热古菌DNA损伤修复、应答及调控
·嗜热古菌细胞周期、蛋白翻译后修饰及其进化
·超嗜热微生物底盘细胞的构建及优化
主要项目:
1、2020/07-2025/06,科技部,国家重点研发计划课题,“极端微生物底盘细胞的设计与构建”-子课题2-4:底盘细胞的功能模块化、调控及高版本底盘细胞的优化,主持。
2、2024/01-2028/12,国家自然科学基金重大项目,“古菌功能演化与真核生物起源”-课题三“古菌类真核生物内膜系统形成和蛋白的功能演化”子课题3-2,主持。
3、2020/09-2025/08,bet365 코리아青年学者未来计划,极端微生物DNA损伤应答、调控及底盘细胞的优化,主持。
4、2020/01-2022/12,国家自然科学基金青年项目,超嗜热古菌Sulfolobus islandicus非典型蛋白激酶家族Rio的功能研究,主持
5、2018/03-2020/12,bet365 코리아基本科研业务费资助项目,硫化叶菌蛋白磷酸化调控DNA修复和细胞周期的研究,主持。
6、中国博士后基金面上资助项目,绿色荧光蛋白在嗜热古菌中的应用研究,2016/09-2018/09,主持。
代表性论文:
1.Jiang Zhichao, Lin Zijia, Gan Qi, Wu Pengju, Zhang Xuemei, Xiao Yuanxi, She Qunxin, Ni Jinfeng, Shen Yulong*,Huang Qihong*. The FHA domain protein ArnA functions as a global DNA damage response repressor in the hyperthermophilic archaeonSaccharolobus islandicus, mBio, 2023, 14(4): e0094223.
2.Xiao Yuanxi, Jiang Zhichao, Zhang Mengqi, Zhang Xuemei, Gan Qi, Yang Yunfeng, Wu Pengju, Feng Xu, Ni Jinfeng, Dong Xiuzhu, She Qunxin,Huang Qihong*, Shen Yulong*; The canonical single-stranded DNA-binding protein is not an essential replication factor but an RNA chaperon inSaccharolobus islandicus,iScience, 2023 26(12): 108389.
3.Wu Pengju, Gan Qi, Zhang Xuemei, Yang Yunfeng, Xiao Yuanxi, She Qunxin, Ni Jinfeng,Huang Qihong*, Shen Yulong*. The archaeal KEOPS complex possesses a functional Gon7 homolog and has an essential function independent of the cellular t6A modification level,mLife, 2023, 2(1): 11-27.
4.Liu Xiaotong, Sun Mengmeng, Xu Ruyi, Shen Yulong,Huang Qihong*, Feng Xu*, She Qunxin. Dissection of Functional Domains of Orc1-2, the Archaeal Global DNA Damage-Responsive Regulator,International journal of Molecular Sciences, 2022, 23: 14609.
5.Xiao Yuanxi﹟, Li Jing﹟, Wu Pengju, Ning Na, Li Jingjing, Shen Yulong,HuangQihong*, Ni Jinfeng*; An alkaline thermostable laccase from termite gut associated strain ofBacillus stratosphericus,International journal of biological macromolecules, 2021, 179: 270-278.
6.Huang Qihong, Lin Zijia, Wu Pengju, Ni Jinfeng, Shen Yulong*; Phosphoproteomic analysis reveals Rio1-related protein phosphorylation changes in response to UV irradiation inSulfolobus islandicusREY15A,Frontiers in Microbiology, 2020, 11: 586025.
7.Ahmad Sohail,Huang Qihong*, Ni Jinfeng, Xiao Yuanxi, Yang Yunfeng, Shen Yulong*; Functional analysis of the NucS/EndoMS of the hyperthermophilic archaeonSulfolobus islandicusREY15A,Frontiers in Microbiology, 2020, 11:607431.
8.Mayaka Joseph Badys﹟,Huang Qihong﹟, Xiao Yuanxi, Zhong Qing, Ni Jinfeng,Shen, Yulong*. The lonely guy (LOG) homologue SiRe_0427 from the thermophilic archaeonSulfolobus islandicusREY15A is a phosphoribohydrolase representing a novel group.Applied and Environmental Microbiology, 2019, 85(20).
9.Feng Xu,Huang Qihong, She Qunxin*. Crenarchaeal 3D genome: A prototypical chromosome architecture for Eukaryotes.Cell, 2019, 179(1): 56-58.
10.Huang Qihong﹟, Mayaka Joseph Badys﹟, Zhong Qing, Zhang Chao, HouGuihua, Ni Jinfeng, Yulong Shen*, Phosphorylation of the archaeal Holliday junction resolvase Hjc inhibits its catalytic activity and facilitates DNA repair inSulfolobus islandicusREY15A.Frontiers in Microbiology, 2019, 10: 1214.
11.Huang Qihong, Ahmad Sohail, Zhai Binyuan, Shen Yulong*. Structure and function of Helicases in Archaea the third domain of life, Elsevier, 2018.9.27.(专著)
12.Huang Qihong, Zhong Qing, Mayaka Joseph Badys, Ni Jinfeng, Shen Yulong*. Autophosphorylation and cross-phosphorylation of protein kinases from the CrenarchaeonSulfolobus islandicus.Frontiers in Microbiology, 2017, 8: 2173.
13.Huang Qihong, Liu Linlin, Liu Junfeng, Ni Jinfeng, She Qunxin*, Shen Yulong*. Efficient 5’-3’ DNA end resection by HerA and NurA is essential for cell viability in the crenarchaeonSulfolobus islandicus.BMC Molecular Biology, 2015, 16: 2.
14.Huang Qihong, Li Yansheng, Zeng Chaoning, Song Tengteng, Yan Zhou, Ni Jinfeng, She Qunxin, Shen Yulong*. Genetic analysis of the Holliday junction resolvases Hje and Hjc inSulfolobus islandicus.Extremophiles, 2015, 19(2): 505-514.
15.钟晴,申玉龙,黄奇洪*.古菌蛋白激酶的研究进展.微生物学报, 2017, 57(9): 1400-1408.
16.黄奇洪,马家兴,倪金凤,申玉龙*.优化的绿色荧光蛋白在超嗜热嗜酸古菌冰岛硫化叶菌中的表达与应用.微生物学报, 2017, 57(9): 1362-1372.