医药微生物技术

石梅

教授
博士/硕士生导师
0532-58631565
个人简介 科研项目 学术论文


教育背景

博士起止时间:毕业院校及专业:2000/09-2004/07bet365 코리아发育生物学

硕士起止时间:毕业院校及专业:1991/09-1994/07山东师范大学遗传学

学士起止时间:毕业院校及专业:1987/09-1991/07山东师范大学生物学

工作经历

起止时间单位名称专业技术职务

2013/09-至今bet365 코리아 - 신뢰할 수 있는 사이트教授

2006/09-2013/08bet365 코리아 - 신뢰할 수 있는 사이트副教授

2004/09-2006/08bet365 코리아 - 신뢰할 수 있는 사이트讲师

1996/09-2004/08bet365 코리아医学院生物化学系讲师

1994/09-1996/08bet365 코리아医学院生物化学系助教

研究方向

1.代谢疾病与人体微生物相关性研究:人体微生物与人类代谢疾病之间的关系及其在疾病发生发展过程中的作用机制;

2.胃肠道菌群参与人体代谢免疫机制研究:胃肠道菌群及代谢物对人体免疫和代谢调控和致病机制;

3.肠胃道病原菌的致癌机制研究:病原菌与宿主粘膜细胞相互作用过程中的信号传递,影响宿主免疫调节和诱导肿瘤发生的过程。病原菌致癌的分子机制。

近期承担课题

1.微生物高通量培养与表征,国家重点研发计划,2021-2026,714万元,课题负责人。

2.肠道微生态与肿瘤和呼吸系统重大疾病相关性以及临床干预研究,院校合作横向项目,2021-2024,300万元,项目负责人。

3.胃部菌群与胃癌发生的相关性及化疗药物与益生菌联合对胃微生态干预研究,青岛科技局惠民项目,2022-2024,50万元,项目负责人。

4.基于肠道菌群调节对军人抑郁症的新诊疗方案的系统分析和评价,bet365 코리아交叉学科研究项目,2019-2021, 25万元,课题共同负责人。

5.益生菌靶向干预对军人幽门螺旋杆菌感染和胃慢性炎症治疗的临床效果评价,bet365 코리아交叉学科研究项目,2021-2023, 30万元,课题共同负责人。

6.新型深海酯酶EstD的催化特性和适应深海低温环境的适冷机制,国家自然科学基金面上,2017-2020,62万元,课题负责人。

7.微生物在海洋生源活性气体循环中的作用与机制,国家重点研发计划,2016-2021,380万元,课题负责人。

8.北极斯瓦尔巴德群岛近海产蛋白酶适冷细菌资源的系统分类与多样性、所产适冷蛋白酶的多样性及环境适应,国家自然科学基金面上,2015-2018,80万元,课题负责人。

9.纳米尺度耐药金黄色葡萄球菌细胞壁的超分子结构及新型M23家族金属蛋白酶Pseudoalterin对其抑制机制与应用,国家自然科学基金面上,2013-2016,70万元,课题负责人。


代表性学术论文

1. Wang YB, Ren MB, Wang YF, Wang L, Liu H, Shi M*, Zhong YH*. Constitutive overexpression of cellobiohydrolase 2 in Trichoderma reesei reveals its ability to initiate cellulose degradation. Engineering Microbiology3, 2023, 100059.

2. Wang L, Xie Y, Chang J, Wang J, Liu H, Shi M*, Zhong YH*.A novel sucrose-inducible expression system and its application for production of biomass-degrading enzymes in Aspergillus niger. Biotechnol Biofuels Bioprod. 2023, 16:23

3. Liu B, Li Y, Suo L, Zhang W, Cao H, Wang R, Luan J, Yu X, Dong L, Wang W, Xu S, Lu S, Shi M*. Characterizing microbiota and metabolomics analysis to identify candidate biomarkers in lung cancer. Front Oncol, 2022, 12:1058436.

4. Shi M, Wang HN, Xie ST, Luo Y, Sun CY, Chen XL, Zhang YZ. Antimicrobial peptaibols, novel suppressors of tumor cells, targeted calcium-mediated apoptosis and autophagy in human hepatocellular carcinoma cells. Mol Cancer, 2010, 9:26-41.

5. Shi M, Zhang T, Sun L, Luo Y, Liu DH, Xie ST, Song XY, Wang GF, Chen XL, Zhou BC, Zhang YZ. Calpain, Atg5 and Bak play important roles in the crosstalk between apoptosis and autophagy induced by influx of extracellular calcium. Apoptosis, 2013, 18:435-451.

6. Shi M, Chen L, Wang XW, Zhang T, Zhao PB, Song XY, Sun CY, Chen XL, Zhou BC, Zhang YZ. Antimicrobial peptaibols from Trichoderma pseudokoningii induce programmed cell death in plant fungal pathogens. Microbiology,2012, 158(Pt 1):166-175.

7. Luo Y, Zhang DD, Dong XW, Zhao PB, Chen LL, Song XY, Wang XJ, Chen XL, Shi M*, Zhang YZ. Antimicrobial peptaibols induce defense responses and systemic resistance in tobacco against tobacco mosaic virus. FEMS Microbiol Lett, 2010, 313:120-126.

8. Zhang XY, Han XX, Chen XL, Dang HY, Xie BB, Qin QL, Shi M*, Zhou BC, Zhang YZ. Diversity of cultivable protease-producing bacteria in sediments of Jiaozhou Bay, China. Front Microbiol, 2015, 6:1021.

9. Liu C, Zhang XY, Song XY, Su HN, Qin QL, Xie BB, Chen XL, Zhang YZ, Shi M*. Algimonas arctica sp. nov., isolated from intertidal sand, and emended description of the genus Algimonas. Int J Syst Evol Microbiol, 2015, 65:3256-3261.

10. Li DD, Peng M, Wang N, Wang XJ, Zhang XY, Chen XL, Su HN, Zhang YZ, Shi M*. Arcticibacterium luteifluviistationis gen. nov., sp. nov., isolated from Arctic seawater. Int J Syst Evol Microbiol, 2017, 67:664-669.

11. Li DD, Liu C, Zhang YQ, Wang XJ, Wang N, Peng M, Song XY, Su HN, Zhang XY, Zhang YZ, Shi M*. Flavobacterium arcticum sp. nov., isolated from Arctic seawater. Int J Syst Evol Microbiol, 2017, 67:1070-1074.

12. Wang N, Xu F, Zhang XY, Chen XL, Qin QL, Zhou BC, Zhang YZ, Shi M*. Changchengzhania lutea gen. nov., sp. nov., a new member of the family Flavobacteriaceae isolated from Antarctic intertidal sediment. Int J Syst Evol Microbiol, 2017,67:5187-5192.

13. Shi M*, Yan SG, Xie ST, Wang HN. Tip30-induced apoptosis requires translocation of Bax and involves mitochondrial release of cytochrome c and Smac/DIABLO in hepatocellular carcinoma cells. Biochim Biophys Acta, 2008, 1783:263-274.

14. Zhao J, Zhang X, Shi M, Xu H, Jin J, Ni H, Yang S, Dai J, Wu M, Guo Y. TIP30 inhibits growth of HCC cell lines and inhibits HCC xenografts in mice in combination with 5-FU. Hepatology, 200644:205-215.