教育背景：

博士 起止时间：2009.09-2015.12，毕业院校：华中农业大学，专业：微生物学，硕博连读

学士 起止时间：2005.09-2009.06，毕业院校：华中农业大学，专业：生物技术

工作经历：

起止时间 单位名称 专业技术职务

2022.12-至今 bet365 코리아 bet365 코리아，研究员

2017.04-2021.09 英国阿伯丁大学 自然与计算科学学院化学系，博士后

研究方向：

微生物天然产物生物合成与合成生物学

主要项目：

1. 2024.01-2026.12 4α-硫取代鬼臼类候选药物C-S键的生物催化机制，国家自然科学基金青年项目，22307066，主持

2. 2022.12-2027.12bet365 코리아齐鲁青年学者计划学科建设经费，主持

3. 2018.05-2021.04英国BBSRC项目，BB/P00479X/1，Understanding carbazole biosynthetic enzymes: potential for a versatile assay of acyl CoAs，参与，结题。

4. 2017.04-2020.08英国BBSRC项目，BB/P00380X/1，Elucidating and Engineering Legonmycin Biosynthesis: a framework for heterobicyclic biotransformation，参与，结题。

代表性论文：

1.Wang, S.^#,*, Wu, K.^#, Tang, Y. J.*, & Deng, H.*. Dehydroamino acid residues in bioactive natural products.Natural Product Reports, 2024, 41, 273-297.

2.Wang, S.^#, Sixing, L.^#, Fang, Q., Roland, G., Lu, Z., Gao, Y., Clarke, D. J., Wu, K., Trembleau, L., Yu, Y., Kyeremeh, K., Milne, B. F., Tabudravu, J., & Deng, H.*. Structure and biosynthetic investigation of a ribosomally synthesized and post-translationally modified peptide containing a β-enamino acid and a macrocyclic motif.Nature Communications,2022, 13(1), 5044.

3.Wang, S.^#, Brittain, W^#., Zhang, Q.^#,Lu, Z., Tong, M. H., Wu, K., Kyeremeh, K., Jenner M., Yu, Y., Cobb, S. L., & Deng, H.*. Aminoacyl Chain Translocation Catalysed by a Type II Thioesterase Domain in an Unusual Non-Ribosomal Peptide Synthetase.Nature Communications, 2022, 13(1), 62.

4.Wang, S.^#,*, Fang, Q.^#, Lu, Z., Gao, Y., Trembleau, L., Ebel, R., Andersen, J. H., Philips, C., Law, S., & Deng, H.*. Discovery and biosynthetic investigation of a new antibacterial dehydrated non-ribosomal tripeptide.Angewandte Chemie International Edition, 2021, 60(6), 3229-3237.

5.Wang, S., Liu, K., Xiao, L., Yang, L., Li, H., Zhang, F.,Lei, L., Li, S., Feng, Xu., Li, A., & He, J.*. Characterization of a novel DNA glycosylase fromS. sahachiroiinvolved in the reduction and repair of azinomycin B induced DNA damage.Nucleic acids research, 2016, 44(1), 187-197.

6.Wang, S.*, & Deng, H.*. Peculiarities of promiscuousL-threonine transaldolases for enantioselective synthesis of β-hydroxy-α-amino acids.Applied Microbiology and Biotechnology, 2021, 105(9), 3507-3520.

7.Wang, S., & Deng, H.*. The X-factor: Enhanced β-oxidation on intracellular triacylglycerols enabling overproduction of polyketide drug-like molecules in microorganisms.Synthetic and Systems Biotechnology, 2020, 5(1), 19-20.

8.Wang, S., Zhao, R., Liu, K., Zhu, M., Li, A., & He, J.*. Essential role of an unknown geneaziU3in the production of antitumor antibiotic azinomycin B verified by utilizing optimized genetic manipulation systems forStreptomyces sahachiroi.FEMS microbiology letters, 2012, 337(2), 147-154.

9.Chen, X., Sun, Y.,Wang, S., Ying, K., Xiao, L., Liu, K.,Zuo, X., & He, J.*. Identification of a novel structure-specific endonuclease AziN that contributes to the repair of azinomycin B-mediated DNA interstrand crosslinks.Nucleic acids research, 2020, 48(2), 709-718.

10.Fang, Q., Wu, L., Urwald, C., Mugat, M.,Wang, S., Kyeremeh, K., Philips, C., Law, S., Zhou, Y., & Deng, H*. Genomic scanning enabling discovery of a new antibacterial bicyclic carbamate-containing alkaloid.Synthetic and systems biotechnology, 2021, 6(1), 12-19.

11.Wu, L., Tong, M. H., Raab, A., Fang, Q.,Wang, S.,Kyeremeh, K., Yu, Yi., & Deng, H.*. An unusual metal-bound 4-fluorothreonine transaldolase fromStreptomycessp. MA37 catalyses promiscuous transaldol reactions.Applied microbiology and biotechnology, 2020, 104(9), 3885-3896.

12.Maglangit, F., Alrashdi, S., Renault, J., Trembleau, L., Victoria, C., Tong, M. H., Wang, S., Kyeremeh, K., & Deng, H.*. Characterization of the promiscuous N-acyl CoA transferase, LgoC, in legonoxamine biosynthesis.Organic & Biomolecular Chemistry, 2020, 18(12), 2219-2222.

13.Wang, B., Li, X., Tabudravu, J.,Wang, S., Deng, H.*, & Pan, L.*. The chemical profile of activated secondary metabolites by overexpressing LaeA inAspergillus niger.Microbiological research, 2021, 248, 126735.

14.Valera, A.,Wang, S., Carr, R., Trembleau, L., & Deng, H*. Characterization of a class II ketol-acid reductoisomerase fromMycobacterium tuberculosis.RSC advances, 2022, 12(17), 10540-10544.

15.Zhou, M., Li, Y., Che, H., Sun, Y.,Wang, S., Zhan, Y., Cai, D., & Chen, S. Metabolic Engineering ofBacillus licheniformisfor the Bioproduction of Nicotinamide Riboside from Nicotinamide and Glucose.ACS Sustainable Chemistry & Engineering, 2023, 11(16), 6201-6210.