教育背景

起止时间 毕业院校 专业

博士 2002.03-2005.03 浙江大学 分子生物与生物物理学

硕士 1995.09-1998.07 中科院武汉病毒所 微生物学

本科 1991.09-1995.07 bet365 코리아 微生物学

工作经历

1998.07-2002.03山东省科学院 科研人员

2005.08-至今 bet365 코리아 讲师、副教授

2013.02-2013.10美国德州大学 访问学者

科研方向

1. 微生物生理学

2. DNA损伤与修复

近五年科研项目：

1.山东省重点研发计划（重大科技创新工程）项目，发酵、养殖等行业高浓度氨氮废水高效厌氧脱氮技术与 装备应用示范，2019-2021。

2.科技部科技基础资源调查专项，沿海滩涂特色微生物资源调查。2020-2024。

近五年学术论文：

1.Wu S, Wang J, Wang J, Du X, Ran Q, Chen Q, Sheng D, Li YZ. Corrigendum:Halalkalibacterium roseumgen. nov., sp. nov., a new member of the familyBalneolaceaeisolated from soil. Int J Syst Evol Microbiol. 2022 Jun;72(6).

2.Wu S, Wang J, Wang J, Du X, Ran Q, Chen Q, Sheng D, Li YZ.Halalkalibacterium roseumgen. nov., sp. nov., a new member of the familyBalneolaceaeisolated from soil. Int J Syst Evol Microbiol. 2022. 72(4).

3.Zhuo L, Wan TY, Pan Z, Wang JN, Sheng DH, Li YZ. A Dual-Functional Orphan Response Regulator Negatively Controls the Differential Transcription of Duplicate groELs and Plays a Global Regulatory Role in Myxococcus. mSystems. 2022. e0105621.

4.Wang J, Ran Q, Du X, Wu S, Wang J, Sheng D, Chen Q, Du Z, Li YZ. Two new Polyangium species,P. aurulentumsp. nov. andP. jinanensesp. nov., isolated from a soil sample. Syst Appl Microbiol. 2021. 44(6):126274.

5.Sheng D, Wang Y, Jiang Z, Liu D, Li Y. ImuA facilitates SOS mutagenesis by inhibiting RecA-mediated activity inMyxococcus xanthus. Appl Environ Microbiol. 2021. 87(18):e00919-21.

6.Sheng D, Wang Y, Wu S, Duan R, Li Y. The regulation of LexA on UV induced SOS response inMyxococcus xanthusbased on transcriptome analysis. J Microbiol Biotechnol. 2021. 31(7):912-920.

7.Sheng D, Chen X, Li Y, Wang J, Zhuo L and Li Y. ParC, a New partitioning protein, is necessary for the active form of ParA fromMyxococcuspMF1 plasmid. Front Microbiol. 2021. 11:623699.

8.Liu Y, Wang J, Zhang Z, Wang F, Gong Y, Sheng DH, Li YZ. Two PAAR Proteins with Different C-Terminal Extended Domains Have Distinct Ecological Functions inMyxococcus xanthus. Appl Environ Microbiol. 2021. 87(9):e00080-21.

9.Wang JJ, Wu SG, Chen Q, Sheng DH, Du ZJ, Li YZ.Deinococcus terrestrissp. nov., a gamma ray- and ultraviolet-resistant bacterium isolated from soil. Int J Syst Evol Microbiol. 2020. 70(9):4993-5000.

10.Wu SG, Wang JJ, Wang JN, Chen Q, Sheng DH, Li YZ.Psychroflexus aurantiacussp. nov., isolated from soil in the Yellow River Delta wetlands. Int J Syst Evol Microbiol. 2020. 70(12):6284-6293.

11.Sheng DH, Wang YX, Qiu M, Zhao JY, Yue XJ, Li YZ. Functional Division Between the RecA1 and RecA2 Proteins inMyxococcus xanthus. Front Microbiol. 2020. 11:140.

12.Zhu Y, Xu W, Zhang J, Zhang P, Zhao Z, Sheng D, Ma W, Zhang YZ, Bai L, Pang X. A hierarchical network of four regulatory genes controlling production of the polyene antibiotic candicidin inStreptomycessp. FR-008. Appl Environ Microbiol. 2020.86(9):e00055-20.

13.Chen XJ, Zhang Z, Li YJ, Zhuo L, Sheng DH, Li YZ. Insights into the persistence and phenotypic effects of the endogenous and cryptic plasmid pMF1 in its host strain Myxococcus fulvus 124B02. FEMS Microbiol Ecol. 2020. 96(3):fiaa001.

14.Yang YJ, Singh RP, Lan X, Zhang CS, Sheng DH, Li YQ. Whole transcriptome analysis and gene deletion to understand the chloramphenicol resistance mechanism and develop a screening method for homologous recombination inMyxococcus xanthus. Microb Cell Fact. 2019. 18(1):123.

15.Zhu Y, Zhang P, Zhang J, Xu W, Wang X, Wu L, Sheng D, Ma W, Cao G, Chen XL, Lu Y, Zhang YZ, Pang X. The developmental regulator MtrA binds GlnR boxes and represses nitrogen metabolism genes inStreptomyces coelicolor. Mol Microbiol. 2019.112(1):29-46.

16.Peng Zhang, Zheng Zhang, Zhi-feng Li, Qi Chen, Yao-yao Li, Ya Gong, Xin-jing Yue, Duo-hong Sheng, You-ming Zhang, Changsheng Wu and Yue-zhong Li. Phylogeny-guided characterization of glycosyltransferases for epothilone glycosylation. Microb Biotechnol. 2019. 12(4):763–774.

17.Yang YJ, Singh RP, Lan X, Zhang CS, Li YZ, Li YQ, Sheng DH. Genome Editing in Model StrainMyxococcus xanthusDK1622 by a Site-Specific Cre/loxP Recombination System. Biomolecules. 2018. 8(4):137.

18.Lu T, Zhu Y, Zhang P, Sheng D, Cao G, Pang X. SCO5351 is a pleiotropic factor that impacts secondary metabolism and morphological development inStreptomyces coelicolor. FEMS Microbiol Lett. 2018. 365(17).

19.YJ Yang, Y Wang, ZF Li, Y Gong, P Zhang, WC Hu, DH Sheng and YZ Li. Increasing on target cleavage efficiency for CRISPR/Cas9 induced large fragment deletion inMyxococcusxanthus. Microb Cell Fact. 2017. 16:142.

20.Zhuo L, Zhang Z, Pan Z, Sheng DH, Hu W, Li YZ. CIRCE element evolved for the coordinated transcriptional regulation of bacterial duplicate groELs, Biochim Biophys Acta Gene Regul Mech. 2018. 1861(10):928-937.

21.Sheng XH, Cui CC, Shan C, Li YZ, Sheng DH, Sun B, Chen DZ. O-Phenylenediamine: a privileged pharmacophore of ferrostatins for radical-trapping reactivity in blocking ferroptosis. Org Biomol Chem. 2018. 16(21):3952-3960.

22.Peng R, Wang Y, Feng WW, Yue XJ, Chen JH, Hu XZ, Li ZF, Sheng DH, Zhang YM, Li YZ. CRISPR/dCas9-mediated transcriptional improvement of the biosynthetic gene cluster for the epothilone production inMyxococcus xanthus, Microb Cell Fact. 2018.17(1):15.