教育背景:
(1)2016-09至2021-06,bet365 코리아,微生物学,博士
(2)2012-09至2016-06,齐鲁工业大学,食品质量与安全,学士
工作经历:
(1)2024-03至今,bet365 코리아,bet365 코리아,助理研究员
(2)2021-06至2024-03,bet365 코리아,bet365 코리아,博士后
研究方向:
功能酶的挖掘及改造、多酶级联催化体系的构建、发酵及生物转化过程在线监测及反馈控制、微生物/酶电合成系统的构建与优化、现代化分离纯化技术等,研究工作致力于大宗及精细化学品的绿色生物制造。
主要项目:
(1)山东省自然科学基金青年基金,ZR2022QC150,2023-01至2025-12,在研,主持
(2)山东省博士后创新项目,SDCX-ZG-202203035,2022-09至2024-03,结题,主持
(3)中国博士后科学基金面上项目,2021M701994,2021-11至2024-03,结题,主持
(4)青岛市应用研究项目,2021-09至2024-03,结题,主持
(5)国家自然科学基金面上项目,31971387,2020-01至2023-12,结题,参与
(6)山东省重点研发计划,2019GSF107015,2019-01至2020-12,结题,参与
代表性论文:
1.Wen Xin, Lin Huibin, Tesfay Mesfin Angaw, Ning Yuhang, Liu Guangwen, Ren Yilin, Zhang Chengjia, Lin Jianqun*, Lin Jianqiang*. Bioproduction of high-allulose-fructose syrup from D-glucose catalyzed by recombinantE. colico-expressing glucose isomerase and D-allulose 3-epimerase.Food Bioscience2023, 56, 103222.
2.Wen Xin, Ning Yuhang, Lin Huibin, Ren Yilin, Li Can, Liu Yujie, Zhang Chengjia, Lin Jianqun*, Lin Jianqiang*. D-Allulose (D-psicose) biotransformation from D-glucose, separation by simulated moving bed chromatography (SMBC) and purification by crystallization.Process Biochemistry2022, 119, 29-38.
3.Wen Xin, Lin Huibin, Ning Yuhang, Liu Guangwen, Ren Yilin, Li Can, Zhang Chengjia, Lin Jianqun*, Song Xin*, Lin Jianqiang. D-Allulose (D-Psicose) biotransformation from allitol by a newly found NAD(P)-dependent alcohol dehydrogenase fromGluconobacter frateuriiNBRC 3264 and the enzyme characterization.Frontiers in Microbiology2022, 13, 870168.
4.Wen Xin, Lin Huibin, Ren Yilin, Li Can, Zhang Chengjia, Lin Jianqun*, Lin Jianqiang*. Allitol bioproduction by recombinantEscherichia coliwith NADH regeneration system co-expressing ribitol dehydrogenase (RDH) and formate dehydrogenase (FDH) in individual or in fusion.Electronic Journal of Biotechnology2022, 55, 91-98.
5. Tesfay Mesfin Angaw,Wen Xin, Liu Yujie, Lin Huibin, Chen Linxu, Lin Jianqiang*, Lin Jianqun*. Construction of recombinantEscherichia coliexpressing xylitol-4-dehydrogenase and optimization for enhanced L-xylulose biotransformation from xylitol.Bioprocess and Biosystems Engineering2021,44(6), 1021-1032.
6. Tesfay Mesfin Angaw,Wen Xin, Lin Huibin, Liu Yujie, Li Can, Lin Jianqiang*, Lin Jianqun*. Efficient L-xylulose production using whole-cell biocatalyst with NAD+regeneration system through co-expression of xylitol dehydrogenase and NADH oxidase inEscherichia coli.Biochemical Engineering Journal2021, 175, 108137.
7.Wen Xin, Lin Huibin, Ren Yilin, Li Can, Zhang Chengjia, Song Xin*, Lin Jianqun, Lin Jianqiang*. Efficient allitol bioproduction from D-fructose catalyzed by recombinantE. coliwhole cells, and the condition optimization, product purification.Applied Biochemistry and Biotechnology2020, 192(2), 680-697.
8.Wen Xin, Lin Huibin, Ren Yilin, Li Can, Zhang Chengjia, Song Xin*, Lin Jianqun, Lin Jianqiang*. Optimization for allitol production from D-glucose by using immobilized glucose isomerase and recombinantE. coliexpressing D-psicose-3-epimerase, ribitol dehydrogenase and formate dehydrogenase.Biotechnology Letters2020, 42(11), 2135-2145.
9.温鑫,宁宇航,林慧彬,任一林,林建群*,林建强*。生物转化生产稀有糖醇——阿洛醇(蒜糖醇)研究进展。食品与发酵工业2022,48(1),286-291。
10.温鑫,宁宇航,刘光文,Tesfay Mesfin Angaw,林建强*,任一林,林慧彬,宋欣,林建群。D-阿洛酮糖生物合成研究进展。食品与发酵工业2023,49(1),288-296,312。
11.温鑫,刘光文,宁宇航,Tesfay Mesfin Angaw,林建强*,任一林,林慧彬,宋欣,林建群。D-塔格糖生物合成研究进展。食品与发酵工业2023,49(22),326-333。
专著:
Li Can, Tesfay Mesfin Angaw,Wen Xin, Ning Yuhang, Lin Huibin, Zhang Chengjia, Ren Yilin, Lin Jianqiang, Lin Jianqun. Advances in Biology, Chapter 1 Enzymes for the synthesis of rare sugars, Nova Science Publishers, Inc. † New York, 2022-09-21, 1, 1-47.
授权发明专利:
1.林建强,安高(Tesfay Mesfin Angaw),温鑫,林建群。一种利用双酶级联重组大肠杆菌催化木糖醇生物合成L-木糖的方法,2024-04-05,中国,ZL202211213497.6。
2.林建强,柴玉颖,温鑫,任一林,孙煦茵,宋欣,林建群。一种利用重组胞内RNA支架固定重组酶促进细胞催化阿洛醇生产的方法,2023-05-09,中国,ZL202010160837.8。
3.林建强,温鑫,宋欣,任一林,林建群。一种利用含有NAD(P)-依赖型醇脱氢酶的菌株催化生产D-阿洛酮糖的方法,2022-12-02,中国,ZL202011591904.8。
4.林建强,温鑫,宋欣,任一林,林建群。一种利用NAD(P)-依赖型醇脱氢酶催化生产D-阿洛酮糖的方法,2022-11-25,中国,ZL202011589002.0。
5.林建强,柴玉颖,任一林,孙煦茵,温鑫,林建群。用于细胞内重组蛋白固定的三角形网状RNA支架及其构建方法与应用,2022-06-07,中国,ZL202010161002.4。
获奖情况:
1.温鑫,李灿,林建强,林建群,宋欣。生物转化法生产稀有糖D-阿洛酮糖,2022年中国•山东博士后创新创业成果大赛,创新组优胜奖,2022-09。
2.温鑫。静息细胞转化D-果糖生产阿洛醇,2021年中国•山东(青岛)博士后创新创业成果大赛,创业组优胜奖,2021-09。