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微生物学、生物化学与分子生物学

冯旭

研究员
硕士生导师
个人简介 科研项目 学术论文

教育背景

博士 起止时间:2015-2018毕业院校:哥本哈根大学 专业:生物化学

硕士 起止时间:2011-2014毕业院校:华中农业大学 专业:发酵过程

学士 起止时间:2007-2011毕业院校:华中农业大学 专业:生物工程

工作经历

起止时间 单位名称 专业技术职务

2018.9-2019.8,印第安纳大学,博士后

2019.9-2022.2,bet365 코리아,博士后

2022.3-今,bet365 코리아bet365 코리아,研究员

研究方向

1. 微生物基因组稳定性维持机制

2. CRISPR-Cas工作机制

3. 微生物基因组编辑

科技部重点研发计划项目:新型基因大片段高效定点整合技术的研发及多元化应用, 2023-2028 (参与)

山东省高等学校青创科技支持计划:基于新型可编程核酸酶的高效微生物基因编辑技术的开发;2023-2025(主持)

科技部重点研发计划项目:极端微生物底盘细胞的设计与构建,2020-2025(参与)

国家自然科学基金青年基金项目:古菌首例B家族DNA聚合酶参与DNA形变损伤复制的分子机制。2021-2023(主持)


代表性论文

1.Feng X#*, Xu R#, Liao J, Zhao J, Zhang B, Xu X, Zhao P, Wang X, Yao J, Wang P, Wang X, Han W, She Q*. Flexible TAM requirement of TnpB enables efficient single-nucleotide editing with expanded targeting scope. Nat Commun. 2024 Apr 24;15(1):3464.

2. Blombach F, Sýkora M, Case J,Feng X, Baquero DP, Fouqueau T, Phung DK, Barker D, Krupovic M, She Q, Werner F*. Cbp1 and Cren7 form chromatin-like structures that ensure efficient transcription of long CRISPR arrays. Nat Commun. 2024 Feb 22;15(1):1620.

3. Zhao P, Bi X, Wang X,Feng X, Shen Y, Yuan G, She Q*. Rational design of unrestricted pRN1 derivatives and their application in the construction of a dual plasmid vector system forSaccharolobus islandicus. mLife. 2024; 3: 119–128.

4. Liu X, Sun M, Xu R, Shen Y, Huang Q*,Feng X*, She Q. Dissection of Functional Domains of Orc1-2, the Archaeal Global DNA Damage-Responsive Regulator. Int J Mol Sci. 2022 Nov 23;23(23):14609.

5.Feng X, Zhang B, Gao Z, Xu R, Liu X, Ishino S, Feng M, Shen Y, Ishino Y, She Q*. A Well-Conserved Archaeal B-Family Polymerase Functions as an Extender in Translesion Synthesis. mBio. 2022 Jan 18;13(1)

6.Feng X, Zhang B, Xu R, Gao Z, Liu X, Yuan G, Ishino S, Feng M, Shen Y, Ishino Y, She Q*. Enzymatic Switching Between Archaeal DNA Polymerases Facilitates Abasic Site Bypass. Front Microbiol. 2021 Dec 20;12:802670.

7.Feng X, Liu X, Xu R, Zhao R, Feng W, Liao J, Han W, She Q*.A unique B-Family DNA polymerase facilitating error-prone DNA damage tolerance in Crenarchaeota. Front Microbiol. 2020; 11:1585

8.Feng X, She Q*. Recombinant protein expression in Sulfolobus islandicus. Methods in Enzymology. 2021;659

9.Feng X, Huang Q., She Q.*, Crenarchaeal 3D genome: A prototypical chromosome architecture for eukaryotes, Cell, 2019, 179: 56-58

10. Sun M#,Feng X#, Liu Z, Han W, Liang YX, She Q*. An Orc1/Cdc6 ortholog functions as a key regulator in the DNA damage response in Archaea. Nucleic Acids Res. 2018 Jul 27;46(13):6697-6711

11.Feng X, Sun M, Han W, Liang YX, She Q*. A transcriptional factor B paralog functions as an activator to DNA damage-responsive expression in archaea. Nucleic Acids Res. 2018 Aug 21;46(14):7085-7096

12. Peng W, Feng M,Feng X, Liang YX, She Q*. An archaeal CRISPR type III-B system exhibiting distinctive RNA targeting features and mediating dual RNA and DNA interference. Nucleic Acids Res. 2015 Jan;43(1):406-17.