教育背景
博士 :2008.09-2013.06毕业院校:bet365 코리아 专业:微生物学
学士 :2004.09-2008.06毕业院校:bet365 코리아 专业:生物科学
工作经历
2018.9-至今 bet365 코리아bet365 코리아 副教授
2018.1-2018.8 bet365 코리아bet365 코리아 讲师
2013.11-2015.12 bet365 코리아环境科学与工程学院 博士后
2013.9-2017.12 bet365 코리아生命科学学院 讲师
研究方向
1.乳酸菌生理代谢与遗传操作系统
2.乳酸菌合成生物学与活性化合物高效生产
3.乳酸菌(原)噬菌体及其生理作用与潜在应用
主要项目:
1.国家自然科学基金面上项目《原噬菌体介导干酪张抵抗胃酸胁迫的分子机制研究》2024-2027
2.国家重点研发计划青年科学家项目《治疗炎症性肠病的合成肠道菌群的构建及应用》2020-2024
3.山东省自然科学基金面上项目《基于CRISPR关联转座酶的乳酸菌基因组靶向整合系统》2021-2023
代表性论文
1.Xiaoning Xu#, Lingwen Zhang#, Yue Cui, Jian Kong,Tingting Guo*.2024.Development of Zn2+-controlled expression system for lactic acid bacteria and its application in engineered probiotics. Syn Syst Biotechno 9:152-158.
2.Tingting Guo, Yue Cui, Lingwen Zhang, Xiaoning Xu, Zhenxiang Xu, Jian Kong*. 2022. Holin‐assisted bacterial recombinant protein export. Biotechnol Bioeng 119:2908-2918.
3.Jiapeng Wu, Xingfang Tian, Xiaoning Xu, Xinyi Gu, Jian Kong,Tingting Guo*. 2022. Engineered ProbioticLactococcus lactisfor Lycopene Production against ROS Stress in Intestinal Epithelial Cells. ACS Synth Bio 11:1568-1576.
4.Jiapeng Wu, Yongping Xin, Jian Kong*,Tingting Guo*. 2021. Genetic tools for the development of recombinant lactic acid bacteria. Microb Cell Fact 20:118.
5.Xinyi Gu, Tao Yu,Tingting Guo*, Jian Kong*. 2020. A qPCR-based method for rapid quantification of six intestinal homeostasis-relevant bacterial genera in feces. Future Microbiol 16:12.
6.Yongping Xin#,Tingting Guo#, Yi Zhang, Jiapeng Wu, Jian Kong*. 2019. A new β-galactosidase extracted from the infant feces with high hydrolytic and transgalactosylation activity. Appl Microbiol Biotechnol 103:8439-8448.
7.Yongping Xin#, Yingli Mu, Jian Kong,Tingting Guo*. 2019. Targeted and repetitive chromosomal integration enables high yield of heterologous gene expression inLactobacillus casei. Appl Environ Microbiol 85:e00033-19.
8.Tingting Guo#, Yongping Xin#, Yi Zhang, Xinyi Gu, Jian Kong*. 2019. A rapid and versatile tool for genomic engineering inLactococcus lactis. Microb Cell Fact 18:22.
9.Tingting Guo#, Yongping Xin, Chenchen Zhang, Jian Kong*. 2018. A cytoplasmic antiholin is embedded in-frame with the holin in aLactobacillus fermentumbacteriophage. Appl Environ Microbiol 84:e02518-17.
获奖情况
1.2023年山东省轻工业联合会科技进步一等奖(第二位)
2.2022年山东省优秀硕士学位论文指导教师
3.2021年山东省科学技术进步二等奖(第三位)
4.2021年bet365 코리아青年教师教学比赛一等奖
所获专利
1.郭婷婷,孔健,吴佳鹏,辛永平,顾心怡;一种产生番茄红素的重组乳酸乳球菌及其应用;专利号,ZL202011503541.8
2.郭婷婷,孔健,顾心怡;一株人源性产生γ-氨基丁酸的鸟肠球菌及其应用;专利号,ZL202011503328.7