代表性论文
共发表超过210篇论文；H-因子：76；总引逾25500
下列为自2013年来20篇主要研究论文(*为通讯作者论文)。
1. Wang Y, Zong W, Sun W, Chen C, Wang Z-Q*,Li TL*.The Central Domain of MCPH1 Controls Development of the Cerebral Cortex and Gonads in Mice. Cells. Aug 31;11(17):2715. (2022)
2. Kirtay M, Sell J, Marx C, Haselmann H, Ceanga M, Zhou ZW, Rahmati V, Kirkpatrick J, Buder K, Grigaravicius P, Ori A, Geis C*, Wang Z-Q*.ATR regulates neuronal activity by modulating presynaptic firing. Nat Commun. Jul 1;12(1):4067. (2021)
3. Tapias A, Lázaro D, Yin BK, Rasa SMM, Krepelova A, Kelmer Sacramento E, Grigaravicius P, Koch P, Kirkpatrick J, Ori A, Neri F,Wang Z-Q*. HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration. Elife. Feb 17;10:e61531. (2021)
4. Chen Y, Sun J, Ju Z,Wang Z-Q,Li TL*.Nbs1-mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis. Cell Prolif.Feb 14:e12972. (2021)
5. Liu X, Schneble-Löhnert N, Kristofova M, Qing X, Labisch J, Hofmann S, Ehrenberg S, Sannai M, Jörß T, Ori A, Godmann M,Wang Z-Q*. The N-terminal BRCT domain determines MCPH1 function in brain development and fertility.Cell Death DiseaseFeb 1;12(2):143. (2021)
6. Kidiyoor GR, Li Q, Bastianello G, Bruhn C, Giovannetti I, Mohamood A, Beznoussenko GV, Mironov A, Raab M, Piel M, Restuccia U, Matafora V, Bachi A, Barozzi S, Parazzoli D, Frittoli E, Palamidessi A, Panciera T, Piccolo S, Scita G, Maiuri P, Havas KM, Zhou ZW, Kumar A, Bartek J,Wang Z-Q, Foiani M*. ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration.Nat Commun. Sep 24;11(1):4828. (2020)
7. Journiac N, Gilabert-Juan J, Cipriani S, Benit P, Liu X, Jacquier S, Faivre V, Delahaye-Duriez A, Csaba Z, Hourcade T, Melinte E, Lebon S, Violle-Poirsier C, Oury JF, Adle-Biassette H,Wang Z-Q, Mani S, Rustin P, Gressens P*, Nardelli J*. Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.Cell Rep. Apr 14;31(2):107506. (2020)
8. Zhou ZW*, Kirtay M, Schneble N, Yakoub G, Ding M, Rüdiger T, Siniuk K, Lu R, Jiang YN, Li TL, Kaether C, Barzilai A,Wang Z-Q*. NBS1 interacts with Notch signaling in neuronal homeostasis.Nucleic Acids Res. Nov 4;48(19):10924-10939. (2020)
9. Liu X, Zong W, Li TL, Wang Y, Xu X, Zhou ZW*,Wang Z-Q*. The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis. EMBO J.36(24):3666-3681. (2017)
10. Tapias A,Wang Z-Q*. Lysine Acetylation and Deacetylation in Brain Development and Neuropathies.Genomics Proteomics Bioinformatics 5(1):19-36. (2017)
11. Schuhwerk H, Bruhn C, Siniuk K, Min W, Erener S, Grigaravicius P, Krüger A, Ferrari E, Zubel T, Lazaro D, Monajembashi S, Kiesow K, Kroll T, Bürkle A, Mangerich A, Hottiger M,Wang Z-Q*. Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.Nucleic Acids Res. 45(19):11174-11192. (2017)
12. Hoch NC, Hanzlikova H, Rulten SL, Tétreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GM, McKinnon PJ,Wang Z-Q, Wagner JD; Care4Rare Canada Consortium, Yoon G*, Caldecott KW*. XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.Nature541(7635):87-91. (2017)
News & Views by Christopher Ross & Ray Truant: DNA repair: A unifying mechanism in neurodegeneration.Nature 541(7635):34-35 (2017)
13. Hoa NN, Shimizu T, Zhou ZW,Wang Z-Q, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H*. Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.Mol Cell.64(3):580-592. (2016)
14. Li TL, Shi Y, Wang P, Guachalla LM, Sun B, Joerss T, Chen YS, Groth M, Krueger A, Platzer M, Yang YG, Rudolph KL,Wang Z-Q*. Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.EMBO J. 34(12):1630-47. (2015)
Have you seen by Chih-Hong Lou, Eleen Y Shum & Miles F Wilkinson1: RNA degradation drives stem cell differentiation.EMBO J. 34(12):1606-8. doi: 10.15252/embj.201591631 (2015)
15. Artandi SE, Blau HM, Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Munoz-Canoves P, Rodewald HR, Wagers A,Wang Z-Q, Yamashita Y. Stem Cells and Aging: What’s Next? Cell Stem Cell 16, 578-81 (2015)
16. Bruhn C, Kroll T,Wang Z-Q*.. Systematic characterization of cell cycle phase-dependent protein dynamics and pathway activities by high-content microscopy-assisted cell cycle phenotyping.Genomics Proteomics Bioinformatics 12(6):255-65.(2014) (Cover story)
17. Tapias A, Zhou ZW, Shi Y,Chong Z, Wang P,Groth M, Platzer M, Huttner W, Herceg Z, Yang YG,Wang Z-Q*. Trrap-dependent histone acetylation specifically regulates cell cycle gene transcription to control neural progenitor fate decisions.Cell Stem Cell 14,632-643. (2014) (Cover story).
18. Min WK, Bruhn C,Grigaravicius P, Zhou ZW, Li F, Krüger A, Siddeek B,Greulich KO,Popp O, Meisezahl CF, Calkhoven C, Bürkle A, Xu XZ,Wang Z-Q*. Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation.Nat Commun. 4:2993, doi: 10.1038/ncomms3993.(2013)
19.Zhang P, Kasagi S, Maruyama T, Wei G, Konkel JE, Nakatsukasa H, Abbatiello B,Wang Z-Q, Zhao K, Chen WJ*. PARP-1 regulates expression of TGF-beta receptors in T cells.Blood 122(13):2224-32. (2013)
20.Zhou ZW, Liu C, Li TL, Bruhn C, Krueger A,Min WK,Wang Z-Q*, Carr A*. An Essential Function for the ATR-Activation-Domain (AAD) of TopBP1 in Mouse Development and Cellular Senescence.PLoS Genetics 9(8):e1003702. (2013)
其他学术称号和荣誉
欧洲科学院院士(The Academia Europaea，MAE)
广州暨南大学荣誉教授，中国医学科学院北京协和医学院客座教授，首都师范大学特聘教授，第四军医大学肿瘤研究协同中心海外专家，复旦大学遗传发育协同创新中心特聘教授，浙江大学“动物分子营养” 海外学术大师联合工作室特聘教授，德国耶拿大学终身教授。
世界抗癌联盟中国分会(UICC-CACA)海外专员，中国科学院北京基因组研究所国外专家，中国科学院“海外评审专家”，中国国际技术转移中心专家顾问。北京市基因组稳定性重点实验室顾问委员会委员，广东省DNA损伤应答重点实验室顾问委员会委员，德国马普研究学会顾问委员会评委。
学术兼职
汪兆琦应邀担任诸多国际国内科学研究基金会评委（超过30家机构）包括：中国自然科学基金委，中国科学院高端人才计划，欧盟第六框架计划，欧洲研究委员会(ERC)，人类前沿科学计划 (Human Frontier), 英国癌症研究会(CRUK)， 英国医学研究理事会(MRC)，英国Wellcome Trust基金会，英国生物技术及生物科学理事会(BBSRC，UK）；英国国际肿瘤研究基金会(AICR)，英国A-T研究基金会，美国国立卫生研究院(NIH)，NIH-以色列基金会（美国），以色列科技空间部，法国肿瘤研究基金会，法国国家研究基金会(ANR), 德国科学研究基金会(DFG)，德国洪堡基金会，德国勃林格殷格海姆基金会(Boehringer Ingelheim,)；德国恩斯特仙灵基金会(Ernst Schering Foundation); 奥地利科学研究基金会（FWF），意大利肿瘤协会基金会，意大利Telethon基金会，瑞士国家科学基金会(SNSF), 荷兰国家科学研究会(NWO), 俄罗斯科学基金会，新加坡国家医学研究会，新加坡A＊STAR生物医学研究会，等等。
受邀为诸多顶尖生物医学杂志审稿，包括Nature, Cell, Science, Nature Cell Biology, Nature Genetics, Nature Medicine, Nature Communications, Molecular Cell, Cell Stem Cell, Cancer Cell, Neuron, EMBO J, Proc. Natl. Acad. Sci. USA (PNAS), Gene & Development, Science Transl. Med., Science Advances, Nuclear Acid Research等。
招贤纳士
本实验室长期招聘硕士研究生，博士研究生，博士后、科研助理等科研人员。我们热烈欢迎喜欢肠道菌群研究的本科生加入本实验室从事毕业设计和报考本实验室研究生，我们期待抱有强烈原创兴趣的学生和青年科学家同仁加盟，共同探索生命奥秘。
联系方式：zhao-qi.wang@sdu.edu.cn（邮件同时转发：201999900022@sdu.edu.cn；wenzong@sdu.edu.cn）。
